There have been active development and implementation of the science, technology, engineering, arts and mathematics (STEAM) education in South Korean K-12 classrooms. In addition, Technology Education (TE) has contributed to the development and diffusion of STEAM education as a major practitioner. However, there is relatively little research in the fields related to biotechnology, which is the main learning content of technology education. This program consists of activities in which students create a smart farm based on physical computing and explore the growth process of plants. Accordingly, the purpose of this study is to develop a biotechnology STEAM program centered on technology problem solving and to verify its effectiveness. Middle school students from the technology club participated in the experiment. The students investigated the principles of smart farms and made them. It was intended to cultivate convergence competency through research and creating activities while directly raising plants. Participants were interviewed before and after the experiment. As a result of the experiment, the biotechnology STEAM program (i) promotes the technology literacy of students. and (ii) promote scientific inquiry by students. (iii) It helps to develop problem-solving skills. In conclusion, this study confirms the effectiveness of the high-tech-based biotechnology STEAM program. However, for the validity of the program, it must be applied to many experiment participants, and the applicability of the developed program must also be proven by teachers.